منابع مشابه
Induction of host matrix metalloproteinases by Borrelia burgdorferi differs in human and murine lyme arthritis.
Matrix metalloproteinases (MMPs) are induced from host tissues in response to Borrelia burgdorferi. Upregulation of MMPs may play a role in the dissemination of the organism through extracellular matrix tissues, but it can also result in destructive pathology. Although mice are a well-accepted model for Lyme arthritis, there are significant differences compared to human disease. We sought to de...
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These results support and extend the observations of Gharavi et al.' They provide further evidence that antidsDNA and anticardiolipin antibodies are to some extent discrete populations in the patients with principally IgGl and IgG3 anticardiolipin binding-that is, the principal subclasses of IgG anti-dsDNA, showed no DNA binding. These results also emphasise the heterogeneity of anticardiolipin...
متن کاملMatrix metalloproteinases: role in arthritis.
The irreversible destruction of the cartilage, tendon, and bone that comprise synovial joints is the hallmark of both rheumatoid arthritis (RA) and osteoarthritis (OA). While cartilage is made up of proteoglycans and type II collagen, tendon and bone are composed primarily of type I collagen. RA is an autoimmune disease afflicting numerous joints throughout the body; in contrast, OA develops in...
متن کاملDual role of interleukin-10 in murine Lyme disease: regulation of arthritis severity and host defense.
In the murine model of Lyme disease, C3H/He mice exhibit severe arthritis while C57BL/6N mice exhibit mild lesions when infected with Borrelia burgdorferi. Joint tissues from these two strains of mice harbor similar concentrations of B. burgdorferi, suggesting that the difference in disease severity reflects differences in the magnitude of the inflammatory response to B. burgdorferi lipoprotein...
متن کاملRole of osteopontin in murine Lyme arthritis and host defense against Borrelia burgdorferi.
Several genetic loci in the mouse have been identified that regulate the severity of Lyme arthritis. The region of chromosome 5 including the osteopontin (OPN) gene (Opn) has been identified in intercross populations of C3H/HeN x C57BL/6 and C3H/HeJ x BALB/cAnN mice. OPN is of particular interest as it is involved in the maintenance and remodeling of tissue during inflammation, it regulates pro...
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ژورنال
عنوان ژورنال: Arthritis & Rheumatism
سال: 2001
ISSN: 0004-3591,1529-0131
DOI: 10.1002/1529-0131(200106)44:6<1401::aid-art234>3.0.co;2-s